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Bioprospecting macroalgae, marine and terrestrial invertebrates & their associated microbiota
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Costa-Lotufo, Leticia Veras

; Colepicolo, Pio

; Pupo, Mônica Tallarico

; Palma, Mario Sergio

Biota Neotropica

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2022, Volume 22 Nº spe elocation e20221345

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo A presente revisão discute o impacto das iniciativas de bioprospecção desenvolvidas pelos projetos associados ao BIOprospecTA, subprograma do programa BIOTA, apoiado pela FAPESP. Esta revisão traz um resumo dos principais resultados produzidos pelos projetos de investigação de produtos naturais (PNs) de organismos não vegetais, como exemplos do sucesso desta iniciativa, com foco nos avanços alcançados pelos projetos relacionados a PNs de macroalgas, invertebrados marinhos, artrópodes e microrganismos associados. As macroalgas são um dos grupos mais estudados no Brasil com o isolamento de muitas substâncias bioativas, incluindo lipídios, carotenóides, ficocolóides, lectinas, aminoácidos do tipo micosporina e substâncias halogenadas. Invertebrados marinhos e microrganismos associados têm sido estudados de forma mais sistemática nos últimos trinta anos, revelando substâncias únicas, com potentes atividades biológicas. Os venenos de insetos himenópteros também foram amplamente estudados, resultando na identificação de centenas de peptídeos, que foram utilizados para criar uma biblioteca química que contribuiu para a identificação de modelos para o desenvolvimento de substâncias antifúngicas, antiparasitárias e anticancerígenas. O conhecimento construído dos venenos de himenópteros permitiu o desenvolvimento de um soro equino anti-peçonha de abelha. Dentre os microrganismos associados a insetos, a estratégia de bioprospecção foi compreender as bases moleculares das interações intra e interespécies (Ecologia Química), traduzindo esse conhecimento para possíveis aplicações biotecnológicas. Os resultados aqui discutidos reforçam a importância do programa BIOprospecTA no desenvolvimento de pesquisas com alto potencial inovador no Brasil.

Abstract The present review aims the discussion of the impact of the bioprospection initiative developed by the projects associated to BIOprospecTA, a subprogram of the program BIOTA, supported by FAPESP. This review brings a summary of the main results produced by the projects investigating natural products (NPs) from non-plants organisms, as examples of the success of this initiative, focusing on the progresses achieved by the projects related to NPs from macroalgae, marine invertebrates, arthropods and associated microorganisms. Macroalgae are one of the most studied groups in Brazil with the isolation of many bioactive compounds including lipids, carotenoids, phycocolloids, lectins, mycosporine-like amino acids and halogenated compounds. Marine invertebrates and associated microorganisms have been more systematically studied in the last thirty years, revealing unique compounds, with potent biological activities. The venoms of Hymenopteran insects were also extensively studied, resulting in the identification of hundreds of peptides, which were used to create a chemical library that contributed for the identification of leader models for the development of antifungal, antiparasitic, and anticancer compounds. The built knowledge of Hymenopteran venoms permitted the development of an equine hyperimmune serum anti honeybee venom. Amongst the microorganisms associated with insects the bioprospecting strategy was to understand the molecular basis of intra- and interspecies interactions (Chemical Ecology), translating this knowledge to possible biotechnological applications. The results discussed here reinforce the importance of BIOprospecTA program on the development of research with highly innovative potential in Brazil.

https://doi.org/10.1590/1676-0611-bn-2022-1345

Nutritional value changes in response to temperature, microalgae mono and mixed cultures
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Militão, Frederico Pacheco

; Fernandes, Valéria de Oliveira

; Bastos, Kathiani Victor

; Martins, Aline Paternostro

; Colepicolo, Pio

; Machado, Levi Pompermayer

Acta Limnologica Brasiliensia

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2019, Volume 31 elocation e17

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivo Avaliar o desenvolvimento de Pseudopediastrum boryanum (Turpin) E. Hegewald e Scenedesmus obliquus (Turpin) Kützing em cultivos unialgais e mistos, em três diferentes temperaturas, 20, 30 e 40 °C, em escala laboratorial, em termos de biomassa e composição bioquímica. Métodos O cultivo foi do tipo batelada, em meio ASM1. A densidade celular foi determinada por contagem direta em hemocitômetro a cada dois dias. As análises dos principais pigmentos se deram em dois tempos e as análises de proteínas, carboidratos, lipídeos totais e perfil de ésteres metílicos apenas ao final do experimento. Resultados Não foi registrado crescimento celular nas cepas cultivadas em 40 °C. Incremento na densidade celular (13.6 x 106 cell.mL-1) e biomassa (55 g.L-1) foram registrados na cultura unialgal de S. obliquus em 30 °C. Elevadas concentrações de proteínas (672.6 mg.g-1) foram observadas nos cultivos unialgais de P. boryanum e de S. obliquus em 20 °C e de carboidratos (6.17 mg.g-1) apenas no cultivo unialgal de P. boryanum em 30 °C. Os FAMEs (fatty acid methyl esteres) variaram significativamente em relação ao número de insaturações, sendo constituídos em sua maioria por ácidos graxos com duas ou mais insaturações. Conclusões A biomassa dos tratamentos analisados foi rica em proteínas, ácidos graxos essenciais, como o ácido linolênico, e apresentou baixo teor de carboidratos, sugerindo seu potencial uso como suplemento alimentar. Nossos resultados indicam que a cultura mista de P. boryanum e S. obliquus não foi uma condição eficiente para a produção de biomassa ou compostos bioquímicos. No entanto, algas cultivadas em consórcio apresentaram melhor estabilidade em sua composição bioquímica em resposta a mudanças de temperatura, fator importante para a produção de microalgas em lagoas abertas e para garantir a segurança alimentar. Estes resultados sugerem que os consórcios entre diferentes espécies de microalgas devem ser testados para determinar melhores metodologias para produção de biomassa e metabólitos com maior estabilidade à fatores ambientais.

Abstract Aim The response of mixed cultures and monocultures of Pseudopediastrum boryanum (Turpin) E. Hegewald and Scenedesmus obliquus (Turpin) Kützing was assessed in the laboratory at three different temperatures: 20, 30 and 40 °C. The change in biomass and biochemical composition of these cultures was evaluated. Methods Microalgae were placed in a batch culture over 21-days in ASM1 medium. Cell density was directly counted every two days using a Fuchs-Rosenthal hemocytometer. Chlorophyll ‘a’ and total carotenoids were extracted twice. Protein, carbohydrate, total lipid and fatty acid contents were determined at the end of the experiment. Results Cultures grown in 40 °C exhibited no growth. However, there was increased cell density (13.6 x 106 cell.mL-1) and biomass (55 g.L-1) in the S. obliquus monoculture at 30 °C. High protein concentrations (672.6 mg.g-1) were observed in monocultures P. boryanum and S. obliquus at 20 °C treatments. There were high carbohydrate concentrations (6.17 mg.g-1) in P. boryanum unialgal at 30 °C. There was no significant difference in total lipid content between S. obliquus (95.5 mg.g-1), P. boryanum (96.3 mg.g-1) and the mixed culture at 20 °C (105.3 mg.g-1). FAMEs varied significantly regarding the number of unsaturated components, which predominantly consisted of fatty acids with two or more unsaturated bonds. Conclusions The biomass of the treatments analyzed was rich in proteins and essential fatty acids (such as linolenic acid), yet low in carbohydrate content, suggesting its potential use as a food supplement. Our results indicate that mixed culture of P. boryanum and S. obliquus was inefficient in cultivating biomass or biochemical compounds as compared to the unialgal cultivations. However, algae grown together showed better stability in their biochemical composition in response to changes in temperature, an important factor for microalgae production in open ponds and in food safety measures. These results suggest the consortia among different species of microalgae should be tested to determine better methodologies for the production of biomass and metabolites with greater stability towards environmental factors.

https://doi.org/10.1590/s2179-975x7118 1611 downloads

"Sweet Chemistry": a Green Way for Obtaining Selenium Nanoparticles Active against Cancer Cells
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Vieira, Adriana P.

; Stein, Erika M.

; Andreguetti, Daniel X.

; Cebrián-Torrejón, Gerardo

; Doménech-Carbó, Antonio

; Colepicolo, Pio

; Ferreira, Ana Maria D. C.

Journal of the Brazilian Chemical Society

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Out 2017, Volume 28 Nº 10 Páginas 2021 - 2027

Resumo: En | Texto: En | PDF: En

We present an environment friendly synthesis of selenium nanoparticles and the study of their cytotoxic activity against uterine sarcoma cancer and fibroblasts cells. Amorphous selenium (a-SeNPs) and trigonal selenium (t-SeNPs) were synthesized using D-fructose as the reducing agent and characterized by high-resolution transmission electron microscopy (HRTEM), energy-dispersive X-ray spectroscopy (EDX), powder X-ray diffraction analysis (XRD), inductively coupled plasma optical emission spectrometry (ICP OES), dynamic light scattering (DLS) to obtain zeta potential values and cyclic voltammetry (CV). Particularly, a-SeNPs presented high toxicity toward the resistant cancer cell line MES-SA/Dx5 and its parental MES-SA line. However, they are not toxic against P4 fibroblast cells in comparative studies.

https://doi.org/10.21577/0103-5053.20170025 2134 downloads

Evaluation of acetylcholinesterase inhibitory activity of Brazilian red macroalgae organic extracts
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Machado, Levi P.

; Carvalho, Luciana R.

; Young, Maria Cláudia M.

; Cardoso-Lopes, Elaine M.

; Centeno, Danilo C.

; Zambotti-Villela, Leonardo

; Colepicolo, Pio

; Yokoya, Nair S.

Revista Brasileira de Farmacognosia

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Dez 2015, Volume 25 Nº 6 Páginas 657 - 662

Resumo: En | Texto: En | PDF: En

Abstract Alzheimer's disease affects nearly 36.5 million people worldwide, and acetylcholinesterase inhibition is currently considered the main therapeutic strategy against it. Seaweed biodiversity in Brazil represents one of the most important sources of biologically active compounds for applications in phytotherapy. Accordingly, this study aimed to carry out a quantitative and qualitative assessment of Hypnea musciformis (Wulfen) J.V. Lamouroux, Ochtodes secundiramea (Montagne) M.A. Howe, and Pterocladiella capillacea (S.G. Gmelin) Santelices & Hommersand (Rhodophyta) in order to determine the AChE effects from their extracts. As a matter of fact, the O. secundiramea extract showed 48% acetylcholinesterase inhibition at 400 μg/ml. The chemical composition of the bioactive fraction was determined by gas chromatography–mass spectrometry (GC–MS); this fraction is solely composed of halogenated monoterpenes, therefore allowing assignment of acetylcholinesterase inhibition activity to them.

https://doi.org/10.1016/j.bjp.2015.09.003 2036 downloads

Antischistosomal activity from Brazilian marine algae
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Stein, Erika M.

; Machado, Levi P.

; Roffato, Henrique K.

; Miyasato, Patricia A.

; Nakano, Eliana

; Colepicolo, Pio

; Andreguetti, Daniel X.

Revista Brasileira de Farmacognosia

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Dez 2015, Volume 25 Nº 6 Páginas 663 - 667

Resumo: En | Texto: En | PDF: En

Abstract Schistosomiasis may be caused by six different species of the genus Schistosoma. Current treatment is based only on two drugs: oxamniquine, which is only effective against the Schistosoma mansoni species, and praziquantel, which is ineffective against young parasites. Therefore, research on new drugs and their targets for the treatment of this disease is urgently needed. In the present work, the efficacies of several seaweeds extracts against S. mansoni were tested. Worm couples were incubated with different concentration of seaweed extracts for 120 h and monitored after the first 2 h and then every 24 h to evaluate death, mobility reduction and couple detachment. The extracts of 13 different seaweed species were tested in a first trial and the active extracts were further evaluated in lower concentrations. The extracts of Gracilaria ornata and species belonging to the genera Dictyota and Laurencia showed activity at relatively low concentrations. The active extracts were analyzed by LC–MS, and possible candidates are proposed.

https://doi.org/10.1016/j.bjp.2015.09.005 959 downloads

Growth and microcystin production of a Brazilian Microcystis aeruginosa strain (LTPNA 02) under different nutrient conditions
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Bortoli, Stella

; Oliveira-Silva, Diogo

; Krüger, Thomas

; Dörr, Felipe A.

; Colepicolo, Pio

; Volmer, Dietrich A.

; Pinto, Ernani

Revista Brasileira de Farmacognosia

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Ago 2014, Volume 24 Nº 4 Páginas 389 - 398

Resumo: En | Texto: En | PDF: En

Cyanobacteria are prokaryotic and photosynthetic organisms, which can produce a wide range of bioactive compounds with different properties; including a variety of toxic compounds, also known as cyanotoxins. In this work, we describe the isolation of seven cyanobacterial strains from two reservoirs in São Paulo State, Brazil. Seven different chemical variants of microcystins (MC-RR, MC-LR, MC-YR, MC-LF, MC-LW, and two demethylated variants, dm-MC-RR and dm-MC-LR) were detected in three of the ten isolated strains. One particular Microcystis aeruginosa strain (LTPNA 02) was chosen to evaluate its growth by cell count, and its toxin production under seven different nutritional regimes. We observed different growth behaviors in the logarithmic growth period for only three experiments (p <0.05). The total growth analysis identified four experiments as different from the control (p < 0.01). Three microcystin variants (MC-RR, MC-LR and MC-YR) were quantified by liquid chromatography-tandem mass spectrometry. At the experimental end, the toxin content was unchanged when comparing cell growth in ASM-1 (N:P = 1), MLA and BG-11 (N:P = 10) medium. In all other experiments, the lowest microcystin production was observed from cells grown in Bold 3N medium during the exponential growth phase. The highest microcystin content was observed in cultures using BG-11(N:P = 100) medium.

https://doi.org/10.1016/j.bjp.2014.07.019 2877 downloads

New drugs with antiprotozoal activity from marine algae: a review
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Torres, Fábio A.E.

; Passalacqua, Thais G.

; Velásquez, Angela M.A.

; Souza, Rodrigo A. de

; Colepicolo, Pio

; Graminha, Márcia A.S.

Revista Brasileira de Farmacognosia

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Jun 2014, Volume 24 Nº 3 Páginas 265 - 276

Resumo: En | Texto: En | PDF: En

The use of indigenous or remote popular knowledge to identify new drugs against diseases or infections is a well-known approach in medicine. The inhabitants of coastal regions are known to prepare algae extracts for the treatment of disorders and ailments such as wounds, fever and stomach aches, as for the prevention of arrhythmia. Recent trends in drug research from natural sources have indicated that marine algae are a promising source of novel biochemically active compounds, especially with antiprotozoal activity. Algae survive in a competitive environment and, therefore, developed defense strategies that have resulted in a significant level of chemical structural diversity in various metabolic pathways. The exploration of these organisms for pharmaceutical and medical purposes has provided important chemical candidates for the discovery of new agents against neglected tropical diseases, stimulating the use of sophisticated physical techniques. This current review describes the main substances biosynthesized by benthic marine algae with activity against Leishmaniaspp., Trypanosoma cruziand Trypanosoma brucei; the causative agents of leishmaniasis, Chagas disease and African trypanosomiasis, respectively. Emphasis is given to secondary metabolites and crude extracts prepared from marine algae.

https://doi.org/10.1016/j.bjp.2014.07.001 6021 downloads

Effects of a cyanobacterial extract containing-anatoxin-a(s) on the cardiac rhythm of Leurolestes circunvagans
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Rodríguez, Vania

; Mori, Bruno

; Dörr, Felipe A.

; Dal Belo, Cháriston A.

; Colepicolo, Pio

; Pinto, Ernani

Revista Brasileira de Farmacognosia

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Ago 2012, Volume 22 Nº 4 Páginas 775 - 781

Resumo: En | Texto: En | PDF: En

This work presents the effects of an anatoxin-a(s)-containing extract on a cockroach semi-isolated heart preparation and the results supporting the extract’s biological activity on acetylcholinesterase (purified from ell). The presence of the toxin in cyanobacterial strains Anabaena spiroides (ITEP-024, ITEP-025 and ITEP-026) isolated from the Tapacurá reservoir in Pernambuco, Brazil, was confirmed by means of liquid chromatography coupled to an ion-trap mass spectrometer. The anticholinesterase activity was assessed biochemically by the Ellman test and was confirmed by measuring the cockroach’s heart rate. The concentration of the extract containing the tested anatoxin-a(s) (antx-a(s)) (10, 16 and 100 μg.μL-1) inhibited the eel acetylcholinesterase (AChE) by more than 90%. The cockroach cardiac frequency increased by a maximum of about 20% within 29 min after the addition of 2.5x10³ μg of extract containing antxa (s).g-1 bw (n=9, p<0.05). Our results strongly indicate that antx-a(s) is capable of exerting biological effects on cockroach, indicating that more research might be conducted to determine its role in the environment, especially on insects.

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Evaluation of impacts of climate change and local stressors on the biotechnological potential of marine macroalgae: a brief theoretical discussion of likely scenarios
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Horta, Paulo A.

; Vieira-Pinto, Talita

; Martins, Cintia D. L.

; Sissini, Marina N.

; Ramlov, Fernanda

; Lhullier, Cintia

; Scherner, Fernando

; Sanches, Paola F.

; Farias, Julyana N.

; Bastos, Eduardo

; Bouzon, Janayna L.

; Munoz, Pamela

; Valduga, Eduardo

; Arantes, Noele P.

; Batista, Manuela B.

; Riul, Pablo

; Almeida, Rafael S.

; Paes, Eduardo

; Fonseca, Alessandra

; Schenkel, Eloir P.

; Rorig, Leonardo

; Bouzon, Zenilda

; Barufi, José Bonomi

; Colepicolo, Pio

; Yokoya, Nair

; Copertino, Margareth S.

; Oliveira, Eurico C. de

Revista Brasileira de Farmacognosia

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Ago 2012, Volume 22 Nº 4 Páginas 768 - 774

Resumo: En | Texto: En | PDF: En

Climate change can be associated with variations in the frequency and intensity of extreme temperatures and precipitation events on the local and regional scales. Along coastal areas, flooding associated with increased occupation has seriously impacted products and services generated by marine life, in particular the biotechnological potential that macroalgae hold. Therefore, this paper analyzes the available information on the taxonomy, ecology and physiology of macroalgae and discusses the impacts of climate change and local stress on the biotechnological potential of Brazilian macroalgae. Based on data compiled from a series of floristic and ecological works, we note the disappearance in some Brazilian regions of major groups of biotechnological interest. In some cases, the introduction of exotic species has been documented, as well as expansion of the distribution range of economically important species. We also verify an increase in the similarities between the Brazilian phycogeographic provinces, although they still remain different. It is possible that these changes have resulted from the warming of South Atlantic water, as observed for its surface in southeastern Brazilian, mainly during the winter. However, unplanned urbanization of coastal areas can also produce similar biodiversity losses, which requires efforts to generate long-term temporal data on the composition, community structure and physiology of macroalgae.

3337 downloads

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Comparison of extraction and transesterification methods on the determination of the fatty acid contents of three Brazilian seaweed species
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Martins, Aline P.

; Yokoya, Nair S.

; Colepicolo, Pio

Revista Brasileira de Farmacognosia

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Ago 2012, Volume 22 Nº 4 Páginas 854 - 860

Resumo: En | Texto: En | PDF: En

Seaweeds are photosynthetic organisms important to their ecosystem and constitute a source of compounds with several different applications in the pharmaceutical, cosmetic and biotechnology industries, such as triacylglycerols, which can be converted to fatty acid methyl esters that make up biodiesel, an alternative source of fuel applied in economic important areas. This study evaluates the fatty acid profiles and concentrations of three Brazilian seaweed species, Hypnea musciformis (Wulfen) J.V. Lamouroux (Rhodophya), Sargassum cymosum C. Agardh (Heterokontophyta), and Ulva lactuca L. (Chlorophyta), comparing three extraction methods (Bligh & Dyer - B&D; AOAC Official Methods - AOM; and extraction with methanol and ultrasound - EMU) and two transesterification methods (7% BF3 in methanol - BF3; and 5% HCl in methanol - HCl). The fatty acid contents of the three species of seaweeds were significantly different when extracted and transesterified by the different methods. Moreover, the best method for one species was not the same for the other species. The best extraction and transesterification methods for H. musciformis, S. cymosum and U. lactuca were, respectively, AOM-HCl, B&D-BF3 and B&D-BF3/B&D-HCl. These results point to a matrix effect and the method used for the analysis of the fatty acid content of different organisms should be selected carefully.

5008 downloads

11.

Seasonal changes in the pigment composition of natural population of Gracilaria domingensis (Gracilariales, Rhodophyta)
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Pereira, Dinaelza Castelo

; Trigueiro, Thiago Gaban

; Colepicolo, Pio

; Marinho-Soriano, Eliane

Revista Brasileira de Farmacognosia

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Ago 2012, Volume 22 Nº 4 Páginas 874 - 880

Resumo: En | Texto: En | PDF: En

The concentrations of phycobiliproteins (phycoerythrin and phycocyanin), chlorophyll-a and total soluble proteins were determined monthly in three strains (red, green and brown) of Gracilaria domingensis (Kützing) Sonder ex Dickie, collected from natural populations on the coast of Rio Grande do Norte, Brazil. In all the strains, pigment and protein concentrations were higher in the months of less sunlight and greater nitrogen availability and decreased gradually with increased sunlight and decreased nutrient concentration. The red strain showed higher concentrations of phycoerythrin and total soluble proteins. The difference in the concentration of biochemical components over the course of the year indicates species acclimation to different environmental conditions.

3328 downloads Citado 1 vez em SciELO

12.

Characterization of volatile composition of Laurencia dendroidea by gas chromatography-mass spectrometry
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Gressler, Vanessa

; Fujii, Mutue T.

; Colepicolo, Pio

; Pinto, Ernani

Revista Brasileira de Farmacognosia

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Ago 2012, Volume 22 Nº 4 Páginas 805 - 813

Resumo: En | Texto: En | PDF: En

In this study we report the characterization of the volatile compounds of Laurencia dendroidea. Solvent extracts (dichloromethane and methanol), hydrodistillation extracts and headspace solid-phase microextraction samples were obtained and analyzed by GC-MS. Forty-six volatile components were identified in L. dendroidea, among them hydrocarbons, alcohols, phenols, aldehydes, ketones, acids, esters and terpenes.

5933 downloads Citado 1 vez em SciELO

13.

Antioxidant activity and chemical composition of the non polar fraction of Gracilaria domingensis (Kützing) Sonder ex Dickie and Gracilaria birdiae (Plastino & Oliveira)
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Guaratini, Thais

; Lopes, Norberto P.

; Marinho-Soriano, Eliane

; Colepicolo, Pio

; Pinto, Ernani

Revista Brasileira de Farmacognosia

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Ago 2012, Volume 22 Nº 4 Páginas 724 - 729

Resumo: En | Texto: En | PDF: En

Gracilaria domingensis (Kützing) Sonder ex Dickie and Gracilaria birdiae (Plastino & Oliveira) (Gracilariales, Rhodophyta) are seaweeds that occur on the Brazilian coast. Based on their economic and pharmaceutical importance, we investigated the antioxidant activity of the methanolic, ethyl acetate and hexane extracts of both species. The hexane extracts display a high antioxidant activity and comparative analyses indicated G. birdiae as the most active species. Chemical investigation of these fractions showed several carotenoids and fatty acids, as well as cholesterol and sitosterol derivatives. HPLC-DAD analysis of G. birdiae showed violaxanthin (0.04 μg.mg-1 of dry material), antheraxanthin (5.31 μg.mg-1), aloxanthin (0.09 μg.mg-1), zeaxanthin (0.45 μg.mg-1) and β-carotene (0.37 μg.mg-1) as the major carotenoids. G. domingensis showed a similar carotenoid profile, however, with much lower concentration than G. birdiae. Gas chromatography coupled to mass spectrometry was used to determine other nonpolar compounds of these seaweeds. The main compounds detected in both studied species were the fatty acids 16:0; 18:1 Δ9; 20:3 Δ6,9,12, 20:4 Δ5,8,11,14. We found no specificity of compounds in either species. However, G. birdiae, presented higher contents of carotenoids and arachidonic acid than G. domingensis.

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14.

New insights on algal products and bioprospection in Brazil: pharmaceutical, cosmetic and public health applications
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Marinho-Soriano, Eliane

; Pinto, Ernani

; Yokoya, Nair S.

; Colepicolo, Pio

; Teixeira, Valeria Laneuville

; Yoneshigue-Valentin, Yocie

Revista Brasileira de Farmacognosia

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Ago 2012, Volume 22 Nº 4

Resumo: En | Texto: En | PDF: En

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15.

Analyses of photoprotective compounds in red algae from the Brazilian coast
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Cardozo, Karina H. M.

; Marques, Luiza G.

; Carvalho, Valdemir M.

; Carignan, Mario O.

; Pinto, Ernani

; Marinho-Soriano, Eliane

; Colepicolo, Pio

Revista Brasileira de Farmacognosia

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Abr 2011, Volume 21 Nº 2 Páginas 202 - 208

Resumo: En | Texto: En | PDF: En

Qualitative and quantitative studies of mycosporine-like amino acids (MAAs) in three species of the genus Gracilaria Greville (G. birdiae, G. domingensis and G. tenuistipitata) were performed. A simple and efficient extraction procedure based on ethanol was described. HPLC, UV and mass spectrometry experiments revealed different profiles between extracts obtained from one species cultivated in the laboratory (G. tenuistipitata) and two species collected in their natural environment (G. birdiae and G. domingensis). The levels detected in the latter two species were approximately 150 times higher than in the species cultivated in vitro. This study revealed that G. birdiae and G. domingensis present a potential source for economical exploration of MAAs.

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